Urine metabolite changes after cardiac surgery predict acute kidney injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is a serious complication in patients undergoing cardiac surgery, with the underlying mechanism remaining elusive and a lack of specific biomarkers for cardiac surgery-associated AKI (CS-AKI).

Methods

We performed an untargeted metabolomics analysis of urine samples procured from a cohort of patients with or without AKI at 6 and 24 h following cardiac surgery. Based on the differential urinary metabolites discovered, we further examined the expressions of the key metabolic enzymes that regulate these metabolites in kidney during AKI using a mouse model of ischemia-reperfusion injury (IRI) and in hypoxia-treated tubular epithelial cells (TECs).

Results

The urine metabolomic profiles in AKI patients were significantly different from

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC11322674 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature