Comparative metabolite profiling of a metastatic and primary melanoma cell line using untargeted metabolomics: A case study.

ABSTRACT: Melanoma accounts for more than 60% of deaths associated with skin cancer, making its early detection through dermatological screening essential for improved treatment outcomes. Early detection and successful treatment of melanoma can dramatically increase the 5-year survival rate from 14 to 98%. To support such efforts, comprehensive identification of metabolite patterns capable of describing cancer progression will help support the foundational knowledge necessary to build early detection platforms for intervention prior to metastasis. Using an UPLC-MS, as part of a cell-based, untargeted metabolomics approach, we profiled the metabolomes of WM-226-4 and WM-115 cells. Derived from the metastatic and the primary sites of the same individual, these two cell lines represent a paired melanom

SUBMITTER: Yu Z 

PROVIDER: S-EPMC11322782 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature