Urine analysis of 28 designer benzodiazepines by liquid chromatography-high-resolution mass spectrometry.

ABSTRACT: Hundreds of new psychoactive substances (NPS) covering most drugs-of-abuse classes have been introduced to the recreational drug market in recent years. One class of NPS drugs that has become more common recently is "designer" benzodiazepines. Due to a close structural resemblance with prescription benzodiazepines, some of these substances may elicit a positive response (i.e. cross react) in immunoassay screening. Consequently, it is increasingly important to include NPS benzodiazepines during method confirmation to ensure accurate identification of closely-related compounds as well as detection of the benzodiazepines themselves. Here, we present our efforts to develop a screening and confirmation method for detection of 28 NPS benzodiazepines in urine using reversed-phase liquid chromatog

SUBMITTER: Pettersson Bergstrand M 

PROVIDER: S-EPMC11322785 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature