Estimation of withdrawal interval recommendations following administration of fenbendazole medicated feed to ring-necked pheasants (Phasianus colchicus).

ABSTRACT:

Introduction

Prescribing fenbendazole medicated feed for pheasants in the USA is considered extra-label drug use under CPG Sec 615.115, and a safe estimated withdrawal interval (WDI) must be applied following administration to this minor food-producing species. This study sought to determine the pharmacokinetic and residue depletion profile for fenbendazole and its major metabolites to estimate a WDI for pheasants following fenbendazole administration as an oral medicated feed.

Method

Pheasants (n = 32) were administered fenbendazole as an oral medicated feed (100 ppm) for 7 days. Fenbendazole, fenbendazole sulfoxide, and fenbendazole sulfone (FBZ-SO₂) in liver and muscle samples were analyzed using HPLC-UV. Tissue WDIs were estimated using FDA, European Me

SUBMITTER: Carreno Gutiez M 

PROVIDER: S-EPMC11322809 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature