The causal relationship between androgenetic alopecia and serum uric acid: A bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Despite numerous studies investigating the association between androgenetic alopecia (AGA) and serum uric acid (SUA), the causal relationship between AGA and SUA remains unknown.

Methods

We utilized bidirectional Mendelian randomization (MR) to explore the causality between AGA and SUA. Our study chose single nucleotide polymorphisms associated with genome-wide significance (p < 5×10^-8) for the exposure and showing low linkage disequilibrium (R² < 0.001) as IVs. Various MR methods were employed to evaluate causality, including inverse-variance weighted (IVW), Weighted Median, MR-Egger, Weighted Mode and Simple Mode. Sensitivity analyses were performed to test the robustness of the results.

Results

Using the IVW method, we did not find

SUBMITTER: Yu Y 

PROVIDER: S-EPMC11322824 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature