Fabrication of 3D Polycaprolactone Macrostructures by 3D Electrospinning.

ABSTRACT: Building 3D electrospun macrostructures and monitoring the biological activities inside them are challenging. In this study, 3D fibrous polycaprolactone (PCL) macrostructures were successfully fabricated using in-house 3D electrospinning. The main factors supporting the 3D self-assembled nanofiber fabrication are the H₃PO₄ additives, flow rate, and initial distance. The effects of solution concentration, solvent, H₃PO₄ concentration, flow rate, initial distance, voltage, and nozzle speed on the 3D macrostructures were examined. The optimal conditions of 4 mL/h flow rate, 4 cm initial nozzle-collector distance, 14 kV voltage, and 1 mm/s nozzle speed provided a rapid buildup of cylinder macrostructures with 6 cm of diameter, reaching a final height

SUBMITTER: Chinnakorn A 

PROVIDER: S-EPMC11322913 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature