Permselectivity of Silk Fibroin Hydrogels for Advanced Drug Delivery Neurotherapies.

ABSTRACT: A promising trend in tissue engineering is using biomaterials to improve the control of drug concentration in targeted tissue. These vehicular systems are of specific interest when the required treatment time window is higher than the stability of therapeutic molecules in the body. Herein, the capacity of silk fibroin hydrogels to release different molecules and drugs in a sustained manner was evaluated. We found that a biomaterial format, obtained by an entirely aqueous-based process, could release molecules of variable molecular weight and charge with a preferential delivery of negatively charged molecules. Although the theoretical modeling suggested that drug delivery was more likely to be driven by Fickian diffusion, the external media had a considerable influence on the release, with

SUBMITTER: Fernandez-Serra R 

PROVIDER: S-EPMC11323009 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature