Comprehensive classification of TP53 somatic missense variants based on their impact on p53 structural stability.

ABSTRACT: Somatic variation is a major type of genetic variation contributing to human diseases including cancer. Of the vast quantities of somatic variants identified, the functional impact of many somatic variants, in particular the missense variants, remains unclear. Lack of the functional information prevents the translation of rich variation data into clinical applications. We previously developed a method named Ramachandran Plot-Molecular Dynamics Simulations (RP-MDS), aiming to predict the function of germline missense variants based on their effects on protein structure stability, and successfully applied to predict the deleteriousness of unclassified germline missense variants in multiple cancer genes. We hypothesized that regardless of their different genetic origins, somatic missense vari

SUBMITTER: Tam B 

PROVIDER: S-EPMC11323084 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature