Effects of ambient temperature on pediatric incident seizure: A case-crossover analysis using distributed lag non-linear models.

ABSTRACT:

Objective

Emerging evidence supports that brain dysfunction may be attributable to environmental factors. This study aims to examine associations of ambient temperature and temperature variability (TV) with seizure incidence in children, which has not been explored.

Material and methods

Data on 2718 outpatient visits due to seizure were collected in Shanghai, China, from 2018 to 2023. Exposure to ambient temperature was estimated at children's residential addresses using spatial-temporal models. A time-stratified case-crossover design with a distributed lag non-linear model (DLNM) was conducted to assess the association between seizure incidence and daily average of ambient temperature over a period of 21 days prior to a case date of disease onset. For a given case date, we

SUBMITTER: Zhang S 

PROVIDER: S-EPMC11323164 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature