Effects of psilocybin on body weight, body composition, and metabolites in male and female mice.

ABSTRACT: There is growing interest in the therapeutic potential of psilocybin for the treatment of a wide variety of medical problems, and even for the promotion of wellbeing among healthy individuals. Interestingly, among the many proposed indications, both obesity and anorexia nervosa (AN) have been discussed. However, the effect of psilocybin on appetitive behavior and metabolism is not well known. Here, we report the effects of psilocybin on body weight, intake and output, body composition, and metabolic function among lean male and female wild-type mice. In the days immediately following treatment, both male and female mice receiving a single intraperitoneal dose of psilocybin were consistently heavier than saline controls, with no effect of psilocybin on intake or output. Co-administration of

SUBMITTER: Shakir J 

PROVIDER: S-EPMC11323168 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature