The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) and spinal MRIs are often obtained in children with the radiologically isolated syndrome (RIS) for diagnosis and prognosis. Factors affecting the frequency and timing of these tests are unknown.

Objective

To determine whether age or sex were associated with (1) having CSF or spinal MRI obtained or (2) the timing of these tests.

Methods

We analyzed children (≤ 18 y) with RIS enrolled in an international longitudinal study. Index scans met 2010/2017 multiple sclerosis (MS) MRI criteria for dissemination in space (DIS). We used Fisher's exact test and multivariable logistic regression (covariates = age, sex, MRI date, MRI indication, 2005 MRI DIS criteria met, and race).

Results

We included 103 children with RIS (67% girls, med

SUBMITTER: Makhani N 

PROVIDER: S-EPMC11323224 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature