Clinicopathological and cellular senescence biomarkers in chronic stalled wounds.

ABSTRACT:

Background

Chronic wounds have been associated with an elevated burden of cellular senescence, a state of essentially irreversible cell cycle arrest, resistance to apoptosis, and a secretory phenotype. However, whether senescent cells contribute to wound chronicity in humans remains unclear. The objective of this article is to assess the role of clinicopathological characteristics and cellular senescence in the time-to-healing of chronic wounds.

Methods

A cohort of 79 patients with chronic wounds was evaluated in a single-center academic practice from February 1, 2005, to February 28, 2015, and followed for up to 36 months. Clinical characteristics and wound biopsies were obtained at baseline, and time-to-healing was assessed. Wound biopsies were analyzed histologically for

SUBMITTER: Yu GT 

PROVIDER: S-EPMC11323232 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature