Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma.

ABSTRACT: Immune checkpoint inhibitor therapy can provide significant clinical benefit in patients with certain cancer types including melanoma; however, objective responses are only observed for a subset of patients. Mucosal melanoma is a rare melanoma subtype associated with a poor prognosis and, compared with cutaneous melanoma, is significantly less responsive to immune checkpoint inhibitors. Spontaneous canine tumours have emerged as valuable models to inform human cancer studies. In contrast to human melanoma, most canine melanomas are mucosal-an incidence that may be leveraged to better understand the subtype in humans. However, a more comprehensive understanding of the immune landscape of the canine disease is required. Here, we quantify tumour infiltrative T and myeloid cells in canine muco

SUBMITTER: Cronise KE 

PROVIDER: S-EPMC11323233 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature