Water will Find Its Way: Transport through Narrow Tunnels in Hydrolases.

ABSTRACT: An aqueous environment is vital for life as we know it, and water is essential for nearly all biochemical processes at the molecular level. Proteins utilize water molecules in various ways. Consequently, proteins must transport water molecules across their internal network of tunnels to reach the desired action sites, either within them or by functioning as molecular pipes to control cellular osmotic pressure. Despite water playing a crucial role in enzymatic activity and stability, its transport has been largely overlooked, with studies primarily focusing on water transport across membrane proteins. The transport of molecules through a protein's tunnel network is challenging to study experimentally, making molecular dynamics simulations the most popular approach for investigating such eve

SUBMITTER: Sequeiros-Borja C 

PROVIDER: S-EPMC11323245 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature