A Multipurpose Metallophore and Its Copper Complexes with Diverse Catalytic Antioxidant Properties to Deal with Metal and Oxidative Stress Disorders: A Combined Experimental, Theoretical, and In Vitro Study.

ABSTRACT: We report the discovery that the molecule 1-(pyridin-2-ylmethylamino)propan-2-ol (HL) can reduce oxidative stress in neuronal C6 glioma cells exposed to reactive oxygen species (O₂^-•, H₂O₂, and ^•OH) and metal (Cu⁺) stress conditions. Furthermore, its association with Cu²⁺ generates [Cu(HL)Cl₂] (1) and [Cu(HL)₂](ClO₄)₂ (2) complexes that also exhibit antioxidant properties. Potentiometric titration data show that HL can coordinate to Cu²⁺ in 1:1 and 1:2 Cu²⁺:ligand ratios, which was confirmed by monocrystal X-ray studies. The subsequent ultraviolet-visible, electrospray ionization mass spectrometry, and electron paramagnetic resonance e

SUBMITTER: Menezes LB 

PROVIDER: S-EPMC11323273 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature