A novel NIR fluorescent probe for copper(ii) imaging in Parkinson's disease mouse brain.

ABSTRACT: Abnormal copper ion (Cu²⁺) levels are considered to be one of the pathological factors of Parkinson's disease (PD), but the internal relationship between Cu²⁺ and PD progression remains elusive. Visualizing Cu²⁺ in the brain will be pivotal for comprehending the underlying pathophysiological processes of PD. In this work, a near-infrared (NIR) fluorescent probe, DDAO-Cu, capable of detecting Cu²⁺ with exceptional sensitivity (about 1.8 nM of detection limit) and selectivity, rapid response (<3 min), and deep tissue penetration, was designed for quantification and visualization of the Cu²⁺ level. It could detect not only Cu²⁺ in cells but also the changes in the Cu²⁺ level in the rotenone-induced cell and zebrafish

SUBMITTER: Chen J 

PROVIDER: S-EPMC11323298 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature