Association between MAPK and PI3K/Akt signaling pathway-related gene polymorphisms and migraine.

ABSTRACT:

Background

The causes of migraine remain unclear. Evidence suggests that the MAPK and PI3K/Akt signaling pathways play a role in migraine pathogenesis. However, studies on genetic polymorphisms in the two pathways associated with migraine are still limited.

Methods

This study included 226 migraineurs and 452 age- and sex-matched nonmigraine control individuals. Genotyping of 31 Single Nucleotide Polymorphisms (SNPs) in 21 genes was performed. The relationship between migraine and gene polymorphisms was analyzed by using logistic regression. SNP-SNP interactions were examined by a generalized multifactor dimension reduction (GMDR) approach. The possible role of SNPs was evaluated with gene expression data from the GTEx database.

Results

The RASGRP2-rs2230414 GT genotyp

SUBMITTER: Wang M 

PROVIDER: S-EPMC11323340 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature