Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures.

ABSTRACT:

Background

Physiologically based kinetic models facilitate the safety assessment of inhaled engineered nanomaterials (ENMs). To develop these models, high quality datasets on well-characterized ENMs are needed. However, there are at present, several data gaps in the systemic availability of poorly soluble particles after inhalation. The aim of the present study was therefore to acquire two comparable datasets to parametrize a physiologically-based kinetic model.

Method

Rats were exposed to cerium dioxide (CeO₂, 28.4 ± 10.4 nm) and titanium dioxide (TiO_2, 21.6 ± 1.5 nm) ENMs in a single nose-only exposure to 20 mg/m³ or a repeated exposure of 2 × 5 days to 5 mg/m³. Different dose levels were obtained by varying the exposure time for

SUBMITTER: Gosens I 

PROVIDER: S-EPMC11323389 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature