In vivo fluorescence imaging of nanocarriers in near-infrared window II based on aggregation-caused quenching.

ABSTRACT: Accurate fluorescence imaging of nanocarriers in vivo remains a challenge owing to interference derived mainly from biological tissues and free probes. To address both issues, the current study explored fluorophores in the near-infrared (NIR)-II window with aggregation-caused quenching (ACQ) properties to improve imaging accuracy. Candidate fluorophores with NIR-II emission, ACQ984 (λ_em = 984 nm) and IR-1060 (λ_em = 1060 nm), from the aza-BODIPY and cyanine families, respectively, were compared with the commercial fluorophore ICG with NIR-II tail emission and the NIR-I fluorophore P2 from the aza-BODIPY family. ACQ984 demonstrates high water sensitivity with complete fluorescence quenching at a water fraction greater than 50%. Physically embedding the fluorophores illu

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11323397 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature