The spliceosome impacts morphogenesis in the human fungal pathogen Candida albicans.

ABSTRACT: At human body temperature, the fungal pathogen Candida albicans can transition from yeast to filamentous morphologies in response to host-relevant cues. Additionally, elevated temperatures encountered during febrile episodes can independently induce C. albicans filamentation. However, the underlying genetic pathways governing this developmental transition in response to elevated temperatures remain largely unexplored. Here, we conducted a functional genomic screen to unravel the genetic mechanisms orchestrating C. albicans filamentation specifically in response to elevated temperature, implicating 45% of genes associated with the spliceosome or pre-mRNA splicing in this process. Employing RNA-Seq to elucidate the relationship between mRNA splicing and filamentation, we

SUBMITTER: Lash E 

PROVIDER: S-EPMC11323467 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature