Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease associated with high morbidity and mortality worldwide. Oxidative injury and mitochondrial dysfunction in the airway epithelium are major events in COPD progression.

Methods and results

The therapeutic effects of Progesterone (P4) were investigated in vivo and in vitro in this study. In vivo, in a cigarette smoke (CS) exposure-induced COPD mouse model, P4 treatment significantly ameliorated CS exposure-induced physiological and pathological characteristics, including inflammatory cell infiltration and oxidative injury, in a dose-dependent manner. The c-MYC/SIRT1/PGC-1α pathway is involved in the protective function of P4 against CS-induced COPD. In vitro, P4 co-treatment significan

SUBMITTER: Xie B 

PROVIDER: S-EPMC11323532 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature