RpoS role in antibiotic resistance, tolerance and persistence in E. coli natural isolates.

ABSTRACT:

Background

The intrinsic concentration of RpoS, the second most abundant sigma factor, varies widely across the E. coli species. Bacterial isolates that express high levels of RpoS display high resistance to environmental stresses, such as temperature, pH and osmolarity shifts, but are less nutritional competent, making them less capable of utilising alternative nutrient sources. The role of RpoS in antibiotic resistance and persistence in standard laboratory domesticated strains has been examined in several studies, most demonstrating a positive role for RpoS.

Results

Using disk diffusion assays we examined bacterial resistance to 15 different antibiotics, including β -lactams (penicillins, monobactams, carbapenems and cephalosporins), aminoglycosides, quinolones and anti-f

SUBMITTER: Valencia EY 

PROVIDER: S-EPMC11323705 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature