Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI.

ABSTRACT:

Purpose

Multi-echo, multi-contrast methods are increasingly used in dynamic imaging studies to simultaneously quantify R₂^∗ and R₂. To overcome the computational challenges associated with nonlinear least squares (NLSQ) fitting, we propose a generalized linear least squares (LLSQ) solution to rapidly fit R₂^∗ and R₂.

Methods

Spin- and gradient-echo (SAGE) data were simulated across T₂^∗ and T₂ values at high (200) and low (20) SNR. Full (four-parameter) and reduced (three-parameter) parameter fits were implemented and compared with both LLSQ and NLSQ fitting. Fit data were compared to ground truth using concordance correlation coefficient (CCC) and coefficient of variation (CV). I

SUBMITTER: Keeling EG 

PROVIDER: S-EPMC11323764 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature