Ginseng Radix et Rhizoma enhanced the effect of metoprolol in chronic heart failure by inhibiting autophagy in male C57BL/6J mice.

ABSTRACT:

Background

Ginseng Radix et Rhizoma (GS) is frequently used as an adjuvant therapy for patients with heart failure (HF). Metoprolol is widely used in patients with HF. However, there is no report on the combined effects of GS and metoprolol in patients with HF.

Objective

This study investigated the combined effects of GS and metoprolol in male C57BL/6J mice with HF and the underlying mechanisms.

Materials and methods

We utilized a mouse myocardial HF model to measure the serum levels of creatine kinase (CK) and creatine kinase-MB form (CK-MB) using an automated biochemical analyzer. Lactate dehydrogenase (LDH) and cardiac troponin (cTnT) levels were determined using enzyme-linked immunosorbent assays. Autophagy of myocardial cells was evaluated using transmission elec

SUBMITTER: Zi-Chang N 

PROVIDER: S-EPMC11324128 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature