Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry.

ABSTRACT:

Background

Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here, we examine the feasibility of using cord blood DNAm scores leveraging large external studies as discovery samples to capture the epigenetic signature of maternal smoking and its influence on newborns in White European and South Asian populations.

Methods

We first examined the association between individual CpGs and cigarette smoking during pregnancy, and smoking exposure in two White European birth cohorts (n=744). Leveraging established CpGs for maternal smoking, we constructed a cord blood epigenetic score of maternal smoking that was validated in one

SUBMITTER: Deng WQ 

PROVIDER: S-EPMC11324234 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature