Parathyroid Hormone-Related Protein-Producing Adenocarcinoma Suspicious of Lung Cancer: A Case Report.

ABSTRACT:

Introduction

Lung adenocarcinoma with parathyroid hormone (PTH)-related hypercalcemia is uncommon.

Case presentation

A 69-year-old man was admitted to our hospital due to anorexia and fatigue. Serum calcium (15.0 mg/dL) and carcinoembryonic antigen (361.7 ng/mL) were extremely high, and PTH-related protein (PTH-rP) also elevated (16.7 pmol/L). Systemic computed tomography revealed multiple enlarged lymph nodes and disseminated peritoneal nodules, with irregularly shaped nodules in the upper lobe in the left lung. Ultrasound-guided biopsy from the axillary lymph node revealed adenocarcinoma. Immunohistological staining showed the tumor cells to be positive for cytokeratin 7 and PTH-rP and negative for cytokeratin 20 and thyroid transcription factor-1. Although the primary ori

SUBMITTER: Hirabayashi M 

PROVIDER: S-EPMC11324281 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature