Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.

ABSTRACT: Neutrophil infiltration occurs in a variety of liver diseases, but it is unclear how neutrophils and hepatocytes interact. Neutrophils generally use granule proteases to digest phagocytosed bacteria and foreign substances or neutralize them in neutrophil extracellular traps. In certain pathological states, granule proteases play a destructive role against the host as well. More recently, nondestructive actions of neutrophil granule proteins have been reported, such as modulation of tissue remodeling and metabolism. Here, we report a completely different mechanism by which neutrophils act nondestructively, by inserting granules directly into hepatocytes. Specifically, elastase-containing granules were transferred to hepatocytes where elastase selectively degraded intracellular calcium chann

SUBMITTER: Ogino N 

PROVIDER: S-EPMC11324315 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature