Novel Metabolites Associated With Blood Pressure After Dietary Interventions.

ABSTRACT:

Background

The blood pressure (BP) etiologic study is complex due to multifactorial influences, including genetic, environmental, lifestyle, and their intricate interplays. We used a metabolomics approach to capture internal pathways and external exposures and to study BP regulation mechanisms after well-controlled dietary interventions.

Methods

In the ProBP trail (Protein and Blood Pressure), a double-blinded crossover randomized controlled trial, participants underwent dietary interventions of carbohydrate, soy protein, and milk protein, receiving 40 g daily for 8 weeks, with 3-week washout periods. We measured plasma samples collected at baseline and at the end of each dietary intervention. Multivariate linear models were used to evaluate the association between metabolit

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11324412 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature