Quantitative analysis of systemic perfusion and cerebral blood flow in the modeling of aging and orthostatic hypotension.

ABSTRACT: Introduction: Orthostatic hypotension (OH) is common among the older population. The mechanism hypothesized by OH as a risk factor for cognitive decline and dementia is repeated transient cerebral blood flow deficiency. However, to our knowledge, quantitative evaluation of cardiac output and cerebral blood flow due to acute blood pressure changes resulting from postural changes is rare. Methods: We report a new fluid-structure interaction model to analyze the quantitative relationship of cerebral blood flow during OH episodes. A device was designed to simulate the aging of blood vessels. Results and Discussion: The results showed that OH was associated with decreased transient cerebral blood flow. With the arterial aging, lesions, the reduction in cerebral blood flow i

SUBMITTER: Cheng H 

PROVIDER: S-EPMC11324494 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature