Microstructural alterations in white matter and related neurobiology based on the new clinical subtypes of Parkinson's disease.

ABSTRACT:

Background and objectives

The advent of new clinical subtyping systems for Parkinson's disease (PD) has led to the classification of patients into distinct groups: mild motor predominant (PD-MMP), intermediate (PD-IM), and diffuse malignant (PD-DM). Our goal was to evaluate the efficacy of diffusion tensor imaging (DTI) in the early diagnosis, assessment of clinical progression, and prediction of prognosis of these PD subtypes. Additionally, we attempted to understand the pathological mechanisms behind white matter damage using single-photon emission computed tomography (SPECT) and cerebrospinal fluid (CSF) analyses.

Methods

We classified 135 de novo PD patients based on new clinical criteria and followed them up after 1 year, along with 45 healthy controls (HCs). We utilize

SUBMITTER: Yuan X 

PROVIDER: S-EPMC11324559 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature