Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline.

ABSTRACT:

Background

Individuals with subjective cognitive decline (SCD) are at risk of developing Alzheimer's Disease (AD). Traditional seed-based analysis has shown biased functional connectivity (FC) in SCD individuals. To investigate unbiased altered FC by the brain-wide association study (BWAS) and to determine its association with cognition in SCD individuals.

Methods

Measure of association (MA) analysis was applied to detect significant voxels with FC changes. Based on these changes, we identified regions of interest (ROIs) and conducted ROI-wise FC analyses. Correlation analyses were then performed between these FC circuits and cognition.

Results

MA analysis identified 10 ROIs with significantly altered voxels. ROI-wise FC analyses revealed 14 strengthened FC, predomina

SUBMITTER: Huang S 

PROVIDER: S-EPMC11324595 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature