Lipidomic profiling of plasma in a healthy Singaporean population to identify ethnic specific differences in lipid levels and associations with disease risk factors.

ABSTRACT:

Background

Plasma lipids (i.e., cholesterol, low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and triglycerides) are linked to a range of metabolic diseases, including heart disease and diabetes. Plasma lipid species have similarly been associated with the same diseases. However, neither abundance profiling of plasma lipid species in healthy populations, nor differences between ethnic groups has not been reported.

Methods

In this study, we have profiled over 280 lipid species using liquid chromatography-tandem mass spectrometry, independently across two sites, in 359 healthy Singaporean individuals of Chinese (n = 122), Indian (n = 120) and Malay (n = 117) ethnicity.

Results

We found variations in abundance (defined as % coefficie

SUBMITTER: Begum H 

PROVIDER: S-EPMC11324612 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature