Altered adrenal and gonadal steroids biosynthesis in patients with burn injury.

ABSTRACT:

Introduction

Burn injury inevitably leads to changes in the endogenous production of cytokines, as well as adrenal and gonadal steroids. Previous studies have reported gender-related differences in outcome following burn injury, which suggests that gonadal steroids may play a role. The aim of this study was to assess alterations in concentration of endogenous steroids in patients with burn injury.

Methods

For this single-center, prospective descriptive study, high-sensitivity liquid chromatography tandem mass spectrometry (LC-MS/MS)-based steroid quantification was used to determine longitudinal profiles of the concentrations of endogenous steroids in plasma from sixteen adult male patients with burn injury (14.5-72% of total body surface area). Steroids were extracted from

SUBMITTER: Bergquist M 

PROVIDER: S-EPMC11324613 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature