C-reactive protein (CRP) evaluation in human urine using optical sensor supported by machine learning.

ABSTRACT: The rapid and sensitive indicator of inflammation in the human body is C-Reactive Protein (CRP). Determination of CRP level is important in medical diagnostics because, depending on that factor, it may indicate, e.g., the occurrence of inflammation of various origins, oncological, cardiovascular, bacterial or viral events. In this study, we describe an interferometric sensor able to detect the CRP level for distinguishing between no-inflammation and inflammation states. The measurement head was made of a single mode optical fiber with a microsphere structure created at the tip. Its surface has been biofunctionalized for specific CRP bonding. Standardized CRP solutions were measured in the range of 1.9 µg/L to 333 mg/L and classified in the initial phase of the study. The real samples obtai

SUBMITTER: Cierpiak K 

PROVIDER: S-EPMC11324656 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature