Cancer/testis antigen expression and co-expression patterns in gastroesophageal adenocarcinoma.

ABSTRACT: Gastroesophageal adenocarcinoma (GEAC) poses a significant challenge due to its poor prognosis and limited treatment options. Recently, Cancer/testis antigens (CTAs) have emerged as potential therapy targets due to their high expression in tumor cells and their immunogenic nature. We aimed to explore the expression and co-expression of CTAs in GEAC. We analyzed 63 GEAC patients initially and validated our findings in 329 patients from The Cancer Genome Atlas (TCGA) database. CTA expression was measured after RNA sequencing, while clinical information, including survival outcomes and treatment details, was collected from an institutional database. Co-expression patterns among CTAs were determined using Spearman correlation analysis. The majority of the study cohort were male (87%), Caucasia

SUBMITTER: Kalvapudi S 

PROVIDER: S-EPMC11324668 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature