Determining the relationship of p16^INK4a and additional molecular markers of aging with clinical frailty in hematologic malignancy.

ABSTRACT:

Purpose

Older adults with hematologic malignancies (HM) have unique challenges due to age and fitness. The primary aim of this pilot study was to benchmark the ability of multiple biomarkers of aging (p16, epigenetic clocks, T cell gene expression profiles, and T cell receptor excision circles (TREC) to identify frailty as measured by a clinical impairment index (I²) in patients with HM.

Methods

70 patients newly diagnosed with HM had peripheral blood T lymphocytes (PBTL) analyzed for p16^INK4a expression using the OSU_Senescence Nanostring CodeSet. PBTL epigenetic age was measured using 7 epigenetic clocks, and TREC were quantified by qRT-PCR. A composite clinical impairment index (I²) was generated by combining values from 11 geriatric metri

SUBMITTER: Rosko AE 

PROVIDER: S-EPMC11324703 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature