Synthetic magnetic resonance-based relaxometry and brain volume: cutoff values for predicting neurocognitive outcomes in very preterm infants.

ABSTRACT:

Background

Early neurorehabilitation can enhance neurocognitive outcomes in very preterm infants (<32 weeks), and conventional magnetic resonance imaging (MRI) is commonly used to assess neonatal brain injury; however, the predictive value for neurodevelopmental delay is limited. Timely predictive quantitative biomarkers are needed to improve early identification and management of infants at risk of neurodevelopmental delay.

Objective

To evaluate the potential of quantitative synthetic MRI measurements at term-equivalent age as predictive biomarkers of neurodevelopmental impairment and establish practical cutoff values to guide clinical decision-making.

Materials and methods

This retrospective study included 93 very preterm infants who underwent synthetic MRI at term-

SUBMITTER: Vanderhasselt T 

PROVIDER: S-EPMC11324712 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature