Retinal Microvasculature Causally Affects the Brain Cortical Structure: A Mendelian Randomization Study.

ABSTRACT:

Purpose

To reveal the causality between retinal vascular density (VD), fractal dimension (FD), and brain cortex structure using Mendelian randomization (MR).

Design

Cross-sectional study.

Participants

Genome-wide association studies of VD and FD involving 54 813 participants from the United Kingdom Biobank were used. The brain cortical features, including the cortical thickness (TH) and surface area (SA), were extracted from 51 665 patients across 60 cohorts. Surface area and TH were measured globally and in 34 functional regions using magnetic resonance imaging.

Methods

Bidirectional univariable MR (UVMR) was used to detect the causality between FD, VD, and brain cortex structure. Multivariable MR (MVMR) was used to adjust for confounding factors, including bo

SUBMITTER: Wei X 

PROVIDER: S-EPMC11324828 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature