Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.

ABSTRACT: Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, N_effective = 387,649) and from the Million Veteran Program and the Psychiatric Genomics Consortium meta-analyses for alcohol use disorder (AUD, N_effective = 296,974), cannabis use disorder (CanUD, N_effective = 161,053), opioid use disorder (OUD, N_effective = 57,120), and problematic tobacco use (PTU, N_effective = 270,120). SNP-based heritability was estimated for each of the traits

SUBMITTER: Koller D 

PROVIDER: S-EPMC11324857 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature