Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.

ABSTRACT: Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of biomarker-guided therapy for adult patients with primary brain cancers in the real-world setting within the molecular tumor board Freiburg, Germany. We analyzed genetic profiles, personalized treatment recommendations, and clinical outcomes of 102 patients with 21 brain tumor types. Alterations in the cell cycle, BRAF, and mTOR pathways most frequently led to personalized treatment recommendations. Molecularly informed therapies were recommended in 71% and implemented in 32% of patients with completed molecular diagnostics. The disease control rate following

SUBMITTER: Kuehn JC 

PROVIDER: S-EPMC11324882 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature