Saliva-derived DNA is suitable for the detection of clonal haematopoiesis of indeterminate potential.

ABSTRACT: Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with many adverse health outcomes. However, further research is required to understand the critical genes and pathways relevant to CHIP subtypes, evaluate how CHIP clones evolve with time, and further advance functional characterisation and therapeutic studies. Large epidemiological studies are well placed to address these questions but often collect saliva rather than blood from participants. Paired saliva- and blood-derived DNA samples from 94 study participants were sequenced using a targeted CHIP-gene panel. The ten genes most frequently identified to carry CHIP-associated variants were analysed. Fourteen unique variants associated with CHIP, ten in DNMT3A, two in TP53 and two in TET2, were identified with a va

SUBMITTER: O'Reilly RL 

PROVIDER: S-EPMC11324896 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature