Dynamic cell culture modulates colon cancer cell migration in a novel 3D cell culture system.

ABSTRACT: The progression of cancer cell migration, invasion and subsequent metastasis is the main cause of mortality in cancer patients. Through creating more accurate cancer models, we can achieve more precise results, which will lead to a better understanding of the invasion process. This holds promise for more effective prevention and treatment strategies. Although numerous 2D and 3D cell culture systems have been developed, they poorly reflect the in vivo situation and many questions have remained unanswered. This work describes a novel dynamic 3D cell culture system aimed at advancing our comprehension of cancer cell migration. With the newly designed cultivation chamber, 3D tumor spheroids were cultivated within a collagen I matrix in the presence of fluid flow to study the migration of cance

SUBMITTER: Mohamadian Namaqi M 

PROVIDER: S-EPMC11324956 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature