Adapting and facilitating responses in mouse somatosensory cortex are dynamic and shaped by experience.

ABSTRACT: Sensory adaptation is the process whereby brain circuits adjust neuronal activity in response to redundant sensory stimuli. Although sensory adaptation has been extensively studied for individual neurons on timescales of tens of milliseconds to a few seconds, little is known about it over longer timescales or at the population level. We investigated population-level adaptation in the barrel field of the mouse somatosensory cortex (S1BF) using in vivo two-photon calcium imaging and Neuropixels recordings in awake mice. Among stimulus-responsive neurons, we found both adapting and facilitating neurons, which decreased or increased their firing, respectively, with repetitive whisker stimulation. The former outnumbered the latter by 2:1 in layers 2/3 and 4; hence, the overall population respon

SUBMITTER: Dobler Z 

PROVIDER: S-EPMC11324963 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature