Pharmacovigilance analysis of orlistat adverse events based on the FDA adverse event reporting system (FAERS) database.

ABSTRACT:

Objective

Based on the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database, we analyzed the signals of potential adverse events (AEs) of orlistat in the real world to provide a reference for its safe clinical use.

Methods

The FAERS database and OpenVigil 2.1 were used to obtain data on adverse events of orlistat from the first quarter of 2004 to the first quarter of 2023, and to analyze the population in which the adverse events occurred. And the signals of their potential adverse events were mined using reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN) and empirical Bayesian geometric mean (EBGM).

Result

A total of 21,079 reports of adverse events with orlistat as the p

SUBMITTER: Zhu J 

PROVIDER: S-EPMC11324990 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature