Reach-dependent reorientation of rotational dynamics in motor cortex.

ABSTRACT: During reaching, neurons in motor cortex exhibit complex, time-varying activity patterns. Though single-neuron activity correlates with movement parameters, movement correlations explain neural activity only partially. Neural responses also reflect population-level dynamics thought to generate outputs. These dynamics have previously been described as "rotational," such that activity orbits in neural state space. Here, we reanalyze reaching datasets from male Rhesus macaques and find two essential features that cannot be accounted for with standard dynamics models. First, the planes in which rotations occur differ for different reaches. Second, this variation in planes reflects the overall location of activity in neural state space. Our "location-dependent rotations" model fits nearly all m

SUBMITTER: Sabatini DA 

PROVIDER: S-EPMC11325044 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature