Association between APOE genotypes and metabolic syndrome in a middle aged and elderly Urban South Indian population.

ABSTRACT:

Background

This study examines the association between apolipoprotein E (APOE) genotypes and metabolic syndrome (MetS) in an older urban population in South India, as part of the Tata Longitudinal Study on Aging.

Methods

A total of 618 participants aged 45 and above were analyzed cross-sectionally for the association between APOE carrier status and MetS (based on both NCEP ATP III and Consensus criteria).

Results

Despite the high prevalence of MetS observed in this cohort (51.62 % by NCEP-ATP III and 61.33 % by Consensus criteria), multivariable logistic regression revealed no significant association between APOE genotypes and MetS under both criteria. However, specific associations were noted in age and sex-stratified analyses; notably, E2 carriers under 60 showed 0.

SUBMITTER: Azhuvalappil S 

PROVIDER: S-EPMC11325077 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature