Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties.

ABSTRACT: S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these processes. However, many of these analogs are chemically unstable that largely limits their practical application. We have developed a new compound, SAM-P _H , which contains an H-phosphinic group (-P(O)(H)OH) instead of the SAM carboxylic group. SAM-P _H is significantly more stable than SAM, retains functional activity in catechol-O-methyltransferase and methyltransferase WBSCR27 reactions. The last is associated with Williams-Beuren syndrome. Rac-SAM-P _H

SUBMITTER: Rudenko AY 

PROVIDER: S-EPMC11325224 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature