Increased expression of formyl peptide receptor-1 by basophils from patients with mastocytosis.

ABSTRACT:

Background

Symptoms in patients with systemic mastocytosis (SM) are associated with an increase in mast cell burden and release of mast cell-derived mediators. The most frequent presentation of SM is indolent SM (ISM), with moderate symptoms and prognosis. Basophil numbers in these patients are generally normal. However, when examining basophil activation in patients with ISM, we noted an abnormal response to N-formylmethione-leucyl-phenylalanine (fMLP).

Objective

Our aim was to compare basophil responsiveness to fMLP and anti-IgE in healthy volunteers and patients with ISM and relate the findings to fMLP receptor (FPR) expression.

Methods

Basophils isolated from peripheral blood of 15 patients with ISM and 14 healthy volunteers were stimulated with fMLP or anti-IgE.

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11325225 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature