Sall4 regulates downstream patterning genes during limb regeneration.

ABSTRACT: Many salamanders can completely regenerate a fully functional limb. Limb regeneration is a carefully coordinated process involving several defined stages. One key event during the regeneration process is the patterning of the blastema to inform cells of what they must differentiate into. Although it is known that many genes involved in the initial development of the limb are re-used during regeneration, the exact molecular circuitry involved in this process is not fully understood. Several large-scale transcriptional profiling studies of axolotl limb regeneration have identified many transcription factors that are up-regulated after limb amputation. Sall4 is a transcription factor that has been identified to play essential roles in maintaining cells in an undifferentiated state during deve

SUBMITTER: Erickson JR 

PROVIDER: S-EPMC11325254 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature