Novel analysis of functional relationship linking moyamoya disease to moyamoya syndrome.

ABSTRACT:

Objective

The aim of this study was to elucidate the genetic pathways associated with Moyamoya disease (MMD) and Moyamoya syndrome (MMS), compare the functional activities, and validate relevant related genes in an independent dataset.

Methods

We conducted a comprehensive search for genetic studies on MMD and MMS across multiple databases and identified related genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichments analyses were performed for these genes. Commonly shared genes were selected for further validation in the independent dataset, GSE189993. The Sangerbox platform was used to perform statistical analysis and visualize the results. P＜0.05 indicated a statistically significant result.

Results

We included 52 MMD

SUBMITTER: Cao L 

PROVIDER: S-EPMC11325278 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature